Please login or create an account. If you do not have access to this content, you will be shown a 30 second preview and licensing options.

  • Presentation

Zoster Vaccination

Description

The presentation focuses on zoster vaccination, particularly highlighting the importance of prevention of shingles (herpes zoster) through vaccination strategies. It references the historical use of the live attenuated varicella vaccine (Varivax) since 1995 and discusses the need for immunization against chicken pox as a preventive measure against zoster in older populations. The session details the evolution of zoster vaccines, emphasizing the efficacy of Zostavax and the newer Shingrix vaccine, which offers approximately 97% reduction in the incidence of zoster and postherpetic neuralgia in populations over 50. The speaker underscores the advantages of Shingrix, stating it does not contain live virus, which eliminates the risk of contracting chicken pox or shingles from the vaccine itself. Recommendations include vaccination for all adults over 50, irrespective of prior zoster vaccination, and for immunocompromised individuals over 18 years old. Practical considerations about vaccination timing and common side effects are addressed, with an emphasis on the necessity of preventing reactivation of the varicella-zoster virus through effective immunization. The speaker reassures that the risk of adverse reactions is minimal and discusses the implications for those who may not remember having chicken pox, stressing that many adults are seropositive regardless of memory of illness. The lecture concludes on a hopeful note about future vaccination strategies against herpes simplex virus.

View more

Conclusions

  • The Varivax vaccine effectively prevents chickenpox, with immunity lasting over 25 years.
  • Shingles (herpes zoster) vaccination in adults significantly reduces the incidence of zoster and postherpetic neuralgia (PHN).
  • Zostavax, the concentrated version of Varivax, provides a 51% reduction in zoster incidence and a 66% reduction in PHN for vaccinated individuals compared to those who are unvaccinated.
  • Shingrix, the recombinant zoster vaccine, offers approximately 97% efficacy in preventing shingles among individuals aged 50 and older.
  • The efficacy of Shingrix in preventing PHN is also significant, with reductions shown in individuals who develop zoster despite vaccination.
  • Shingrix is preferred over Zostavax for shingles prevention due to its higher efficacy and longer-lasting immunity.
  • The vaccine has been shown to be safe with mild and manageable side effects typical of vaccination.
  • Immunocompromised individuals aged 18 and older are at increased risk for shingles and can be vaccinated with Shingrix.
  • There is no risk of developing chickenpox or shingles from the Shingrix vaccine, as it contains no live virus.
  • N Engl J Med 352: 2271-2284; 2005
  • LaPolla et al. Arch Dermatol 147:901-7; 2011
  • Oxman MN et al. N Engl J Med. 2005:352:2271-2284.
  • Lal et al. N Engl J Med. 2015 May
  • Reference: Prescribing Information for SHINGRIX
  • SHINGRIX: Prevention of PHN from pooled studies 1 and 2 (ZOE-50 and ZOE-70)
  • Reference: Prescribing Information for SHINGRIX
  • Pl Sections 2, 2.1, 2.3, 16.1, and 16.2
  • Pl Sections 14.1, 14.2 and 14.3