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- Presentation
Where's the Evidence? A Critical Evaluation of Common Cosmetic Recommendations - Lasers for Acne
Description
In a review of various acne treatments, the speaker highlights that current evidence does not support any specific alternative treatment, such as lasers, being more effective than traditional methods. However, blue light therapy has shown promise for mild to moderate acne. High-dose photodynamic therapy (PDT) has demonstrated effectiveness for clearer skin, especially when utilizing longer incubation times and higher concentrations of ALA. The presentation discusses the efficacy of new selective lasers targeting sebaceous glands, highlighting two recently FDA-approved devices that utilize 1726 nanometers of light for acne treatment. These devices differ in cooling mechanisms and treatment protocols, but both show significant patient clearance rates, with purported long-lasting effects. Both PDT and retinoids are noted as possible combinations for enhanced treatment outcomes. Overall, the advancements in laser technology and photodynamic therapy represent a shift towards more effective acne treatments that may promise better results than conventional therapies.
View moreConclusions
- Conventional acne treatments have not been outperformed by newer therapies as per current evidence.
- Blue light therapy shows good temporary efficacy for mild to moderate acne.
- High-dose red light photodynamic therapy (PDT) with elevated ALA concentrations is effective for long-term acne treatment.
- Selective photothermolysis effectively targets sebaceous glands, demonstrating significant acne clearance.
- New 1726 nm lasers offer promising results for treating acne across varying skin types, showing durable effects.
- In clinical trials, significant reductions in acne lesions were observed, with durable remission periods of up to 35 months.
- Compared to medical treatments, these laser devices yield much higher rates of acne clearance.
- Br J Dermatol. 2018 Jan;178(1):61-75. doi: 10.1111/bjd.15495. Epub 2017 Oct 16 Light therapies for acne.
- Barbaric J, Abbott R, Posadzki P, Car M, Gunn LH, Layton AM, Majeed A, Car J. Cochrane Database Syst Rev.2016 Sep 27;9(9):CD007917. doi: 10.1002/14651858.CD007917.pub2
- Sakamoto, F.H ., et al ., Selective photothermolysis to target sebaceous glands: theoretical estimation of parameters and preliminary results using a free electron laser. Lasers Surg Med, 2012. 44(2): p. 175-83.
- Goldberg D, Kothare A, Doucette M, Kaur A, Ronan S, Fromowitz J, Hamidi-Sakr A. Selective photothermolysis with a novel 1726 nm laser beam: A safe and effective solution for acne vulgaris.
- Alexiades M, Kothare A, Goldberg D, Dover JS. Novel 1726 nm laser demonstrates durable therapeutic outcomes and tolerability for moderate-to-severe acne across skin types.
- Hongcharu W, J Invest Dermatol. 2000 Aug;115(2):183-92.
- Horfelt C, et al, Acta Derm Venereol. 2007;87(4):325-9.
- Pollock B, et al, Br J Dermatol. 2004 Sep;151(3):616-22.
- Hong SB, Lee MH, Photodermatol Photoimmunol. 2005 Dec;21(6):322-5.
- Bryld LE, Jemec GB, J Dermatolog Treat. 2006;17(4):222-3.
- Ma Y, et al, Photodiagn Photodyn Ther. 2016 Spt 15;172-81.
- Gozalli MV, Sci Rep. 2016 Jun 7;6:27402.
- Am J Clin Dermatol. 2017 Jun;18(3):311-321. doi: 10.1007/s40257-017-0255-3.
- F. Sakamoto et al. J Amer Acad Dermatol 2010 Aug;63(2):183-93.
- Slutsky-Bank E, Artzi O, Sprecher E, Koren A. A split-face clinical trial of conventional red-light photodynamic therapy versus daylight photodynamic therapy for acne vulgaris. J Cosmet Dermatol. 2021 Dec;20(12):3924-3930. doi: 10.1111/jocd.14359.
- Nicklas C, Rubio R, Cárdenas C, Hasson A. Comparison of efficacy of aminolaevulinic acid photodynamic therapy vs. adapalene gel plus oral doxycycline for treatment of moderate acne vulgaris - A simple, blind, randomized, and controlled trial. Photodermatol Photoimmunol Photomed. 2019 Jan;35(1):3-10.
- Zhang J, Zhang X, He Y, Wu X, Huang J, Huang H, Lu C. Photodynamic therapy for severe facial acne vulgaris with 5% 5-aminolevulinic acid vs 10% 5-aminolevulinic acid: A split-face randomized controlled study. J Cosmet Dermatol. 2020 Feb;19(2):368-374.