What's New in Nail Tumors

The presentation covers recent findings in nail tumors, specifically focusing on various cases associated with high-risk HPV. The first case involved a 32-year-old woman with a history of HPV-related lesions, diagnosed with a pigmented squamous cell carcinoma linked to HPV. It highlights that nearly 50% of nail squamous cell carcinomas stem from HPV, particularly in younger patients, suggesting a potential sexual transmission from genital to digital HPV. Another case detailed a 60-year-old man with a slow-growing tumor, later diagnosed as a digital popular adenocarcinoma related to HPV 42, a rare but aggressive cancer originating from sweat glands. The presentation further addresses a rare nail squamous cell papilloma, a benign growth also thought to be HPV-related, and concludes with a unique case of subungual extraskeletal chondroma in a 40-year-old man, marked by specific radiological findings. The speaker emphasizes the importance of recognizing specific characteristics of tumors, especially focusing on melanin patterns in cases of suspected squamous cell carcinoma. This ongoing research showcases the evolving understanding of nail tumors and their associations with HPV, underlining the necessity for awareness of these malignancies.