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- Presentation
What's New in Mohs Surgery: Updates and Advances in Treatment for Melanoma and Squamous Cell Carcinomas
Description
The presentation provides an overview of the latest advancements in Mohs surgery, particularly concerning melanoma and squamous cell carcinomas. It discusses the notable rise in the use of Mohs surgery for early invasive melanoma, with research demonstrating local recurrence rates significantly lower than those achieved with wide local excision. Advances in immunohistochemistry (IHC) have enhanced the effectiveness of frozen section Mohs surgery, which is now favored for challenging melanoma cases. High-risk squamous cell carcinoma is also addressed, emphasizing Mohs surgery's superior outcomes over traditional excision methods, including improved disease-specific survival and reduced recurrence rates. In contrast, the treatment of low-risk squamous cell cancers showcases surgical excision's advantages over topical therapies, though cosmetic outcomes may vary. The presentation briefly mentions Merkel cell carcinoma treatment through Mohs surgery, especially around the head and neck, highlighting its benefits in achieving better functional and cosmetic results. Additionally, the talk reviews perioperative care, emphasizing that routine preoperative antibiotics are unnecessary and that full anticoagulation can typically be maintained during surgeries with minimal complications. Discussing postoperative pain management, the speaker advocates for non-opioid pain relief strategies instead of narcotics, highlighting a regimen involving NSAIDs and acetaminophen. Overall, the updates reflect an evolving practice in dermatologic surgery, focusing on improved patient outcomes and minimizing unnecessary interventions.
View moreConclusions
- Mohs surgery has significantly lower local recurrence rates compared to wide local excision for early invasive melanoma, making it the preferred treatment.
- The use of Mohs surgery for high-risk squamous cell carcinoma (SCC) results in better disease-specific survival compared to traditional wide local excision.
- Mohs surgery may offer improved outcomes for patients with regional nodal disease in high-risk SCC.
- Topical treatments for superficial squamous cell carcinoma have lower sustained clearance rates compared to surgical excision, despite better cosmetic results.
- The routine use of systemic antibiotics for patients undergoing Mohs surgery is not necessary due to low infection rates.
- Continuing anticoagulant therapy during surgical procedures does not lead to serious complications, despite a higher rate of bleeding.
- Tranexamic acid (TXA) is effective in reducing bleeding complications in dermatologic surgical procedures.
- Non-narcotic pain management strategies are recommended as first-line treatments following dermatologic surgery, with opioids being sparingly used.
- JAAD, 2021. Systematic Review And Meta Analysis Of Local Recurrence Rates Of Head And Neck Cutaneous Melanomas after WLE, MMS Or Excision. Sept. 2021.
- Derm Surg, 2022. Local Recurrence of Melanoma is Higher After WLE vs MMS or Staged Excisions: A Systematic Review and Meta-Analysis. Feb. 2022.
- JAAD, 2023. Clinical outcomes of high risk SCC treated with Mohs surgery alone: an analysis of local recurrence, regional nodal metastases, progression free survival and disease specific death. Jan. 2023.
- JAMA Derm, 2023. Validation of the 2022 NCCN Risk Stratification For SCC. July 2023.
- JAAD, 2024. Surgical Excision Versus Topical 5% 5FU and PDT in Treatment of Bowen's Disease: A Multicenter Randomized Controlled Trial. Jan. 2024.
- JAAD, 2022. Efficacy of Nonexcisional Treatment Modalities for Superficially Invasive and In-Situ SCC: A Systemic Review and Meta-Analysis. June 2022.
- JAMA DERM, 2023. Overall Survival after Mohs Surgery for Early Stage Merkel cell carcinoma. Oct 2023.
- Derm Surg, 2021. Evidence-based Clinical Practice Guideline: Reconstruction After Skin Cancer Resection. July 2021.
- Derm Surg, 2022. Systemic literature review of procedure-related risk factors for surgical site infection in dermatologic surgery. Oct. 2022.