Please login or create an account. If you do not have access to this content, you will be shown a 30 second preview and licensing options.
- Presentation
Translating Evidence into Practice: Acne Guidelines and Beyond
Description
The presentation discusses the process of developing acne treatment guidelines, emphasizing the transition from using SORT to GRADE methodologies. The speaker reflects on the challenges faced in evaluating the effectiveness of physical modalities such as lasers, chemical peels, and intralesional steroid injections, highlighting the reliance on randomized controlled trials (RCTs). Due to the limited availability of high-level evidence, the guidelines suggest a cautious approach to these interventions, often yielding conditional recommendations based on moderate certainty of efficacy and risk analysis. Positive outcomes from specific treatments, such as a combined blue and red light therapy and pulse dye lasers, were noted, but challenges in treatment variability, accessibility, and inconsistencies in study sizes were acknowledged. Ultimately, there is insufficient evidence to strongly endorse some treatments while suggesting discontinuation of pneumatic broadband light therapy in combination with adapalene. The presentation concludes with an invitation for further inquiries and the offer to share additional data.
View moreConclusions
- Physical modalities for treating acne vulgaris are under-researched, leading to limited high-level evidence.
- The effectiveness of physical treatments like laser therapy and chemical peels is uncertain due to a lack of randomized controlled trials (RCTs).
- Intralesional corticosteroid injections are strongly recommended for larger papules or nodules as an adjuvant therapy.
- Pneumatic broadband light should not be added to adapalene 0.3% due to a lack of significant benefits and potential adverse effects.
- Certain interventions, such as the combined blue and red light therapies and pulsed dye lasers, show moderate certainty of effectiveness.
- The evidence for the use of microneedle radiofrequency devices and acnes excision is insufficient and does not warrant strong recommendations.
- The variability in treatment protocols and devices presents challenges in making consistent recommendations across the board.
- Andrews et al. Journal of Clinical Epidemiology (2013) 726-735.
- Tangjaturonrusamee, C., P. Rattanaumpawan, and C.M. Ditre, Comparison of pneumatic broadband light plus adapalene gel 0.3% versus adapalene gel 0.3% monotherapy in the treatment of mild to moderate acne. Cutis, 2016. 98(1): p. 56-61.