AAD
Author: Willhemenia Loremipsum Special session: Lorem ipsum dolor sit amet Category: Lorem ipsum View all results

Please login or create an account. If you do not have access to this content, you will be shown a 30 second preview and licensing options.

  • Presentation

Topical Products for Hair Growth

Description

Doctor Levis discussed various topical products for hair growth, emphasizing his personal experience with hair treatments and innovations in the field. He began by reviewing the effectiveness of topical minoxidil, noting its long history in stimulating hair growth by prolonging the anagen cycle, with studies suggesting higher concentrations like 15% may enhance efficacy. He compared topical minoxidil's effectiveness to oral minoxidil, indicating comparable results if patient compliance is managed well. He also addressed topical applications containing finasteride and dutasteride, highlighting their potential benefits and the need for further research. Levis mentioned compounded solutions, including the combination of minoxidil and tretinoin, and shared insights on the use of steroids for androgenic alopecia. The role of microneedling in enhancing product absorption and hair growth was discussed, alongside promising developments in topical peptides and exosomes, with indications of their potential efficacy in stimulating hair follicle activity. He touched upon additional topical treatments like ketoconazole and JAK inhibitors, noting their specific applications and overall effectiveness. Finally, Dr. Levis highlighted new natural DHT blockers and expressed gratitude to his collaborators and fellows for advancing research in hair restoration.

View more

Conclusions

  • Topical minoxidil remains the gold standard for androgenetic alopecia (AGA).
  • Higher concentrations of topical minoxidil (15%) may provide superior results compared to lower doses (5%).
  • Oral minoxidil has shown similar efficacy to topical forms, providing an alternative for those who are non-compliant with topical applications.
  • Topical finasteride and dutasteride may offer effective treatments with lower systemic absorption than oral forms, reducing adverse events.
  • Combining minoxidil with tretinoin can enhance effectiveness without the need for increased frequency of application.
  • Microneedling may improve hair count when used in conjunction with topical treatments like minoxidil but requires larger studies to solidify its efficacy.
  • Topical peptides show potential for stimulating hair growth through various signaling pathways, though more research is needed to validate their effectiveness.
  • Exosomes derived from specific cell types may enhance hair follicle regeneration and improve treatment outcomes for hair loss.
  • Topical JAK inhibitors offer promise for inflammatory alopecias but require more study for general alopecia treatment effectiveness.
  • Natural products like pumpkin seed oil and saw palmetto may have a role in blocking DHT, though evidence is still weak for widespread recommendation.
  • R N Earhart, J Ball, D D Nuss, J L Aeling. Minoxidil-induced hypertrichosis: treatment with calcium thioglycolate depilatory. South Med J. 1977 Apr;70(4):442-3.
  • D A Fenton, J D Wilkinson. Topical minoxidil in the treatment of alopecia areata. Br Med J (Clin Res Ed). 1983 Oct 8;287(6398):1015-7. doi: 10.1136/bmj.287.6398.1015.
  • E E Vanderveen, C N Ellis, S Kang, P Case, J T Headington, J J Voorhees, N A Swanson. Topical minoxidil for hair regrowth. J Am Acad Dermatol. 1984 Sep;11(3):416-21. doi: 10.1016/s0190-9622(84)70183-6.
  • Wolverton SE, Wu JJ, eds. Comprehensive Dermatologic Drug Therapy. 4th ed. Elsevier; 2020.
  • Shreya Singh, Anant Patil, Nika Kianfar, Anna Waśkiel-Burnat, Lidia Rudnicka, Rodney Sinclair, Mohamad Goldust. Does topical minoxidil at concentrations higher than 5% provide additional clinical benefit? Clinical and Experimental Dermatology. 2022; 47(11): 1951-1955. https://doi.org/10.1111/ced.15338.
  • Mariana Alvares Penha, Hélio Amante Miot, Michal Kasprzak. Oral Minoxidil vs Topical Minoxidil for Male Androgenetic Alopecia: A Randomized Clinical Trial. JAMA Dermatol. 2024 Jun;160(6):600-605. doi:10.1001/jamadermatol.2024.0284.
  • Piraccini BM, Blume-Peytavi U, Scarci F, et al. Efficacy and safety of topical finasteride spray solution for male androgenetic alopecia: a phase III, randomized, controlled clinical trial. J Eur Acad Dermatol Venereol. 2022;36(2):286-294. doi:10.1111/jdv.17738. Published correction appears in J Eur Acad Dermatol Venereol. 2023 Feb;37(2):452. doi:10.1111/jdv.18750.
  • Kaiser M, Abdin R, Gaumond SI, Issa NT, Jimenez JJ. Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs. Clin Cosmet Investig Dermatol. 2023 May 31;16:1387-1406. doi: 10.2147/CCID.S385861. PMID: 37284568; PMCID: PMC10239632.
  • Zhi Liu, Xianting Hu, Yuqiong Liang, Jingting Yu, Huabin Li, Maxim N. Shokhirev & Ye Zheng. Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche. Nature Immunology. 2022;23:1086-1097.
  • Cheng M, Ma C, Chen HD, Wu Y, Xu XG. The Roles of Exosomes in Regulating Hair Follicle Growth. Clin Cosmet Investig Dermatol. 2024 Jul 5;17:1603-1612. doi: j10.2147/CCID.S385861.