Therapeutic and Diagnostic Pearls: Preventive Strategies for Patients with High-Risk Cutaneous Squamous Cell Carcinoma

The session focuses on preventive strategies for patients at high risk for cutaneous squamous cell carcinoma (SCC), addressing practical recommendations for non-surgical and adjuvant treatments. The speaker emphasizes the complex nature of SCC, particularly in patients who may have multiple or aggressive cases. Learning objectives include discussing current approaches in chemoprevention, the role of immunotherapy, and management strategies for immunosuppressed patients, such as those post-transplant or on chronic medications that can increase the risk of SCC. Important non-surgical methods mentioned include skin surveillance, injectables like methotrexate and 5-fluorouracil, and topical therapies. The discussion highlights the importance of individualized patient management while considering their unique situations. Furthermore, the speaker suggests encouraging patients to engage in protective measures, such as proper sun protection and monitoring for signs of skin damage. Recent advancements, including the use of systemic retinoids and newer agents for management, indicate evolving treatment paradigms. The conclusion underscores the importance of collaborative care among dermatologists and oncologists, particularly in adjusting immunosuppression strategies to minimize SCC risks in high-risk patients. Overall, the session stresses a holistic approach to treating patients with SCC, considering both immediate treatment needs and long-term preventive strategies.