Systemic Comorbidities of Lichen Planus and Lichen Planopilaris

The presentation addresses systemic comorbidities associated with lichen planus (LP) and lichen planopilaris (LPP), focusing on emerging associations with cardiovascular disease, mood disorders, and autoimmune conditions. It highlights that LP and LPP are inflammatory skin disorders linked to systemic inflammation, as evidenced by elevated inflammatory cytokines in affected patients. Research indicates that individuals with LP have a 1.37-fold increased risk of cardiovascular events and considerable associations with various autoimmune diseases, particularly hypothyroidism, which showcases a 2.88 odds ratio. Additionally, the presentation underscores significant links between LP and psychological conditions such as depression and anxiety, with a notable prevalence difference between affected individuals and controls. Analysis further reveals a significant relationship between LP and respiratory issues like asthma and allergic rhinitis. On the other hand, LPP exhibits notable associations with hypertension, hyperlipidemia, and similar mental health concerns. Overall, the findings suggest that the immunological activities characteristic of lichenoid diseases underpin many systemic comorbidities. The presenter advocates for healthcare providers to recognize these associations to facilitate comprehensive care, encourage routine screenings, and refer patients to specialists as necessary.