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- Presentation
Protect the Skin from NMSC with Laser Treatment
Description
The presentation discusses the protective effects of laser treatments against non-melanoma skin cancer (NMSC), emphasizing that older skin exhibits a decreased response to UVB radiation due to aging fibroblasts' reduced secretion of insulin-like growth factor (IGF-1). This deficiency heightens the risk of NMSC. Research indicates that stimulating fibroblasts with laser treatments can rejuvenate skin, enhancing its ability to resist UV damage, which can potentially decrease the incidence of skin cancers. A retrospective study showed that patients who underwent non-ablative fractional resurfacing had a significantly lower risk of developing facial keratinocyte carcinoma compared to control subjects. The talk also notes ongoing studies assessing various laser technologies' efficacy. Specifically, the 1927 nm wavelength laser is highlighted for its potential to rejuvenate older skin by promoting collagen production and healthier fibroblast morphology. Recommendations for laser treatment frequency are provided, advocating for two to three sessions per year for young patients and stronger treatments for those with more sun damage or actinic keratoses. Overall, the speaker advocates for regular laser treatments as part of a comprehensive skin care regimen to protect against aging and skin cancer.
View moreConclusions
- Age-related decline in fibroblast activity contributes to increased risk of non-melanoma skin cancer (NMSC).
- Laser treatments, especially nonablative fractional laser (NAFL) treatments, can rejuvenate aging skin by increasing fibroblast numbers and activity.
- The presence of insulin-like growth factor (IGF-1) is crucial for skin's response to UV-induced DNA damage, helping prevent skin cancer.
- Research indicates that NAFL treatments are associated with a significantly reduced risk of subsequent facial keratinocyte carcinoma.
- Regular use of laser treatments can normalize skin behavior and provide protective mechanisms against skin cancer.
- Different laser technologies may vary in effectiveness in restoring youthful skin characteristics, with the 1927nm wavelength showing significant benefits.
- Lower levels of senescent fibroblasts and alterations in fibroblast morphology can indicate successful rejuvenation of skin.
- A regimen of low-level laser treatments could be an effective strategy for maintaining skin health and reducing skin cancer risk over time.
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- Frommeyer TC, Rohan CA, Spandau DF, Kemp MG, Wanner MA, Tanzi EL, Travers JB. Wounding Therapies for Prevention of Photocarcinogenesis. Frontiers in Oncology Jan 22.
- Benson TA, Hibler BP, Kotliar D, Avram M. Nonablative Fractional Laser Treatment is Associated with a Decreased Risk of Subsequent Facial Keratinocyte Carcinoma Development. Dermatol Surg Feb 2023; 49:149-154.
- Hibler B, Kagha K, Wilson B, Vazirnia A, Travers J, Spandau M, Tanzi EL, Lima X, Alora M, Wanner M. Impact of Chemical Peels and Fractional Nonablative Laser on Predisposition to Skin Cancer Development in Elderly Skin. Presented at ASDS Annual Meeting 2023.