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- Presentation
Practical Considerations in Avoiding and Detecting Recurrence
Description
The presentation focuses on practical strategies for preventing and detecting recurrence in early-stage basal and squamous cell carcinoma (BCC/SCC) from the perspective of a private practitioner and faculty member. It discusses various risk factors influencing recurrence, including differentiation, size, depth of invasion, and histopathological aspects. The importance of perineural invasion as a prognostic indicator is highlighted, emphasizing the need for careful review of pathology reports. Emerging therapies and genetic profiling are also examined, providing insights into personalized treatment decisions, possibly influencing the use of adjuvant radiation therapy. The discussion touches on the outcomes of recent studies on genetic expression profiling's role in managing low-risk tumors and its potential impact on adjuvant therapy decisions. Other treatment modalities, including immunotherapy, superficial radiation, and photodynamic therapy, are mentioned, noting their effectiveness in specific patient populations. Additionally, the importance of patient education regarding prevention strategies is underlined, along with emerging technologies for detecting recurrence. Overall, the aim is to ensure effective management of skin cancers while minimizing the risks of recurrence through proactive measures and personalized treatment plans.
View moreConclusions
- There are several established risk factors for the recurrence of basal and squamous cell carcinoma, including tumor thickness, histological characteristics, and clinical features.
- Perineural invasion is a particularly strong prognostic indicator for recurrence.
- Emerging treatments like hedgehog pathway inhibitors show promise in improving patient outcomes.
- Genetic profiling can help stratify treatment options and guide decisions on adjuvant therapies.
- Patients presenting with previous basal or squamous cell carcinoma exhibit a higher likelihood of subsequent skin neoplasms.
- Preventive measures, including patient education on skin care and surveillance, are essential in reducing recurrence rates.
- There is ongoing investigation into new therapeutic modalities, like photodynamic therapy, for managing low-risk skin cancers.
- Adjuvant radiation therapy may be more beneficial in certain high-risk cases as determined through genetic expression profiling.
- Multidisciplinary approaches in treatment planning are critical for optimizing patient care.
- Continuous updates to clinical guidelines and treatment strategies are necessary to reflect the latest research findings.
- Rampinelli V, Pinacoli A, and Piazza C. Head and neck nonmelanoma skin cancers: surgical management and debated issues. Curr Opin Otolaryngol Head Neck Surg. 2024; 32: 62-70
- Duarte A, Sousa-Pinto B, Haneke E, and Correia O. Risk factors for development of new skin neoplasms in patients with past history of skin cancer: A survival analysis. Scientific Reports. 2018; 8: 15744
- National Comprehensive Cancer Network. Squamous Cell Skin Cancer. NCCN Clinical Practice Guidelines in Oncology. 2025.
- Rabinowits G, Migden M, Schlesinger T, et al. Evidence-Based Consensus Recommendation for the Evolving Treatment of Advanced Cutaneous Squamous Cell Carcinoma. JID Innovations. 2021;1:100045
- Catalano M, Nozzoli F, De Logu F, et al. Management Approaches for High-Risk Cutaneous Squamous Cell Carcinoma with Perineural Invasion: An Updated Review. Current Treatment Options in Oncology. 2024; 25: 1184-1192
- Haug K, Breuninger H, Metzler G, et al. Prognostic Impact of Perineural Invasion in Cutaneous Squamous Cell Carcinoma: Results of a Prospective Study of 1,399 Tumors. Journal of Investigative Dermatology. 2020; 140: 1968-1975
- Cohen E, Misztal C, Dable C, et al. Redefining Perineural Invasion in Head and Neck Cutaneous Squamous Cell Carcinoma. Otolaryngology-Head and Neck Surgery. 2022;167(4):705-715
- Tomás-Velázquez A, Sanmartin-Jiménez O, Garcés J, et al. Risk Factors and Rate of Recurrence after Mohs Surgery in Basal Cell and Squamous Cell Carcinomas: A Nationwide Prospective Cohort. Acta Derm Venereol. 2021; 101: adv00602
- Li X, Wang H, and Lu Q. Immunotherapy for locally advanced and metastatic basal cell carcinoma: a narrative review. Transl Cancer Res. 2024; 13(11): 6565-6575
- Vergara I, Avazian K, Carlino M, et al. Genomic Profiling of Metastatic Basal cell Carcinoma Reveals Candidate Drivers of Disease and Therapeutic Targets. Modern Pathology 36. 2023; 100099