Practical Approach to the Diagnosis and Management of Cutaneous Graft Versus Host Disease

In this presentation by Sylvina Puglisi and Jasmine Rana, the focus is on Cutaneous Graft Versus Host Disease (GVHD), specifically its diagnosis and management. They first provide an overview of stem cell transplantation, highlighting the increasing number of procedures and the associated risks, including acute and chronic GVHD. The introduction outlines the significant role dermatologists play in diagnosing and treating these conditions, emphasizing the importance of distinguishing between skin complications of GVHD and other potential rashes caused by treatments or underlying conditions. The discussion includes patient cases demonstrating acute GVHD's morbilliform rash, along with its classic presentation and grading based on body surface area. The need for careful differentiation from other conditions like drug rashes and skin infections is underscored. For treatment, the presentation discusses topical therapies, systemic steroids, and newer FDA-approved medications like Ruxolitinib for refractory cases. As they transition into chronic GVHD, they describe its presentation, the timeline of risk, and the critical functions of multiple organ systems affected. Chronic GVHD is portrayed as a distinct entity that may develop following acute GVHD or emerge independently. Treatment options similar to acute GVHD are presented, emphasizing the dermatological management of sclerotic changes. The talk concludes with an acknowledgment of ongoing developments in therapeutic options, reaffirming the dermatological community's vital role in improving patient outcomes.