Please login or create an account. If you do not have access to this content, you will be shown a 30 second preview and licensing options.

  • Presentation

Oldies but Goodies: The Utility of Older Generic Medicines in the Current Practice of Dermatology

Description

In this discussion led by Matt Keller, interim Chair of Dermatology at Thomas Jefferson, the focus is on the relevance and benefits of older generic medications in dermatology, emphasizing their utility despite the availability of newer drugs. The panel, which includes Doctors Elizabeth Jones and Nick Bot, highlights medicines such as cyclosporin, methotrexate, and mycophenolate mofetil. Key reasons for using these older medications include their lower cost, established safety profiles, and accessibility for underserved patients. Keller argues that these medications are particularly important for elderly and fixed-income individuals, as they can avoid complicated prior authorization processes and often come with considerable safety data. The discussion also touches upon the findings from a diversity conference emphasizing the need for understanding these older treatments, especially when serving populations with limited access to newer therapies. Detailed insights into specific conditions, dosing, and patient experiences illustrate the effective use of cyclosporin for psoriasis, mycophenolate mofetil as a steroid-sparing option, and methotrexate's role in managing hypersensitivity reactions in older patients. The session concludes with key takeaways emphasizing the importance of these older, yet effective drugs in providing equitable and affordable healthcare.

View more

Conclusions

  • Older generic medicines like cyclosporine, methotrexate, and mycophenolate mofetil remain relevant and useful in current dermatology due to their cost-effectiveness and established safety profiles.
  • Cycloporine is effective for rapid improvement in severe psoriasis and can be safely used in pregnant women with proper monitoring.
  • Mycophenolate mofetil is a steroid-sparing option suitable for various dermatological conditions, particularly in patients with limited treatment options or those who are elderly.
  • Methotrexate is commonly utilized for idiopathic hypersensitivity responses in older patients and is well tolerated with appropriate monitoring for side effects.
  • In the current healthcare climate, these older medications can help manage costs while providing necessary care to patients, especially those uninsured or underinsured.
  • Pascal R. Beauchesne, Nancy S. C. Chung & Kishor M. Wasan (2007) Cyclosporine A: A Review of Current Oral and Intravenous Delivery Systems, Drug Development and Industrial Pharmacy, 33:3, 211-220, DOI: 10.1080/03639040601155665
  • Tapia C, Nessel TA, Zito PM. Cyclosporine. [Updated 2023 Aug 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan -.
  • Carle F. Paul, et al, Risk of Malignancies in Psoriasis Patients Treated with Cyclosporine: a 5 y Cohort Study, JID, Volume 120, Issue 2, 2003
  • Kim BR, Yang S, Doh EJ, Choi CW, Youn SW. Risk Factors Affecting Adverse Effects of Cyclosporine A in a Real-World Psoriasis Treatment. Ann Dermatol. 2018 Apr;30(2):143-149. https://doi.org/10.5021/ad.2018.30.2.143
  • Balakirski G, Gerdes S, Beissert S, Ochsendorf F, von Kiedrowski R, Wilsmann-Theis D. Therapy of psoriasis during pregnancy and breast-feeding. J Dtsch Dermatol Ges. 2022 May;20(5):653-683. doi: 10.1111/ddg.14789. PMID: 35578438.
  • Pannaphak Hirunsatitpron et al. Br J Clin Pharmacol.2022;88:476-489
  • Yusuf, Sarah et al. Transplantation 104(S3):p S603, September 2020.
  • Hirshberg B, Muszkat M, Schlesinger O, Rubinow A. Safety of low dose methotrexate in elderly patients with rheumatoid arthritis. Postgrad Med J. 2000 Dec;76(902):787-9.