HSV & VZV Updates in Immunocompetent Individuals and People Living with HIV (PLWH)

The talk addressed updates on herpes simplex virus (HSV) and varicella zoster virus (VZV) in immunocompetent individuals and those living with HIV. It began with a brief review of the pathophysiology and epidemiology of HSV and VZV, emphasizing the significance of understanding these common infections, which remain prevalent globally. The speaker highlighted the stigma associated with herpes, tracing its roots to media portrayals and cultural shifts in the 1970s and 1980s that labeled it as a shameful disease. The discussion went on to cover the clinical manifestations of HSV and VZV, including atypical presentations and complications, particularly in immunocompromised patients such as those with HIV, who experience more severe manifestations. Treatment options, along with recent advancements in vaccine development for HSV and VZV, were also reviewed, mentioning the efficacy of existing vaccines like Shingrix and the promise of new HSV vaccines under development by companies such as Moderna and BioNTech. Emphasis was placed on early diagnosis and management to mitigate complications like post-herpetic neuralgia. Ultimately, the talk aimed to destigmatize these infections and highlight their commonality while advocating for better education and understanding among patients.