AAD
Author: Willhemenia Loremipsum Special session: Lorem ipsum dolor sit amet Category: Lorem ipsum View all results

Please login or create an account. If you do not have access to this content, you will be shown a 30 second preview and licensing options.

  • Presentation

Hair Restoration Techniques and Regenerative Therapies

Description

The presentation discusses hair restoration techniques, focusing on different surgical methods and regenerative therapies. Key techniques include Follicular Unit Transplantation (FUT), which entails a linear strip harvesting from the donor site, and Follicular Unit Extraction (FUE), where individual follicles are harvested. Each technique has its own advantages and disadvantages, with FUT offering more follicles but potentially leaving a scar, while FUE is better for individuals who prefer shorter hairstyles but may risk thinning the donor area over time. The speaker highlights the significance of quality control during graft harvesting and emphasizes the importance of post-operative care, noting that results typically manifest within six months to a year. The presentation transitions into discussing regenerative therapies like Platelet-Rich Plasma (PRP) and stem cell-based treatments. PRP, derived from a patient’s blood, has shown promise in improving graft survival and stimulating hair follicle growth, particularly with multiple sessions. The use of exosomes, extracellular vesicles that facilitate cellular communication, is also explored for their potential in hair restoration. Lastly, the presentation touches on biomimetic peptides designed to mimic growth factors, with evidence supporting their use in hair care products. Overall, the presenter advocates for incorporating safe, research-backed therapies while calling for more studies to validate newer options in hair restoration.

View more

Conclusions

  • Hair restoration surgery can be performed using two primary techniques: Follicular Unit Transplantation (FUT) and Follicular Unit Extraction (FUE), each with distinct advantages and disadvantages.
  • FUT provides a greater number of lifetime follicles, quicker harvest times, and is less traumatic to the follicles, but it leaves a potential linear scar.
  • FUE avoids linear scarring and is better suited for patients who prefer to wear their hair short, but it poses a higher risk of thinning the donor area.
  • Patients over 40 and those without a history of keloids are typically good candidates for FUT, while younger patients who may shave their heads may prefer FUE.
  • Regenerative therapies such as Platelet Rich Plasma (PRP) and biomimetic growth factors can be effectively used alongside hair transplantation to enhance results.
  • There are emerging treatments utilizing exosomes and stem cells, but these require more research and face regulatory hurdles before widespread clinical use.
  • The efficacy of PRP has been shown to improve with increased frequency of treatments and proper preparation protocols, indicating that consistency is key for successful outcomes.
  • Biomimetic peptides and growth factors have shown potential in both in vitro and in vivo studies for promoting hair growth but still require further clinical validation.
  • Overall, traditional hair transplantation methods provide reliable and significant results, while newer regenerative therapies offer exciting possibilities that may improve the effectiveness of hair restoration treatments.
  • Shimizu et al. Regenerative medicine strategies for hair growth and regeneration. Regen Ther. 2022;21:527-539.
  • Wang B et al. World J. Stem Cells 2020; 12: 462-70.
  • Gnecchi M et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 2005;11:367-8.
  • Uebel CO, et al. The role of platelet plasma growth factors in male pattern baldness surgery. Plast Reconstr Surg. 2006;118;1458-66.
  • Marx RE. PRP: Evidence to support its use. J Oral Maxillofac Surg 2004; 62:489-96.
  • Li ZJ, Choi H-I, et al. Autologous platelet-rich plasma: A potential therapeutic tool for promoting hair growth. Derm Surg. 2012;38:1040-46.
  • Schiavone G., PRP for androgenetic alopecia: A pilot study. Derm Surg. 2014.
  • Puig, CJ et al. Dermatol Surg. 2016;42:1243-7.
  • Hausauer & Jones. Dermatol Surg. 2018;44:1191-1200.
  • Moftah NH et al. J Cosm Derm. 2022:21:3316-26.
  • Gupta AK, Bamimore MA. J Drugs Derm. 2022:21:943-52.
  • Zhou et al. Frontiers in Pharmacol. 2021:12:Article 642980.
  • Pyo HK, Yoo HG, Won CH et al. The effect of tripeptide-copper complex on human hair growth in vitro. Arch Pharm Res 2007;30:834-9.
  • Trachy RE, Fors TD, Pickart I, Uno H. The hair follicle-stimulating properties of peptide copper complexes. Results in C3H mice. Ann NY Acad Sci 1991;642:468-9.
  • Alexey Alekseevich Kubanov1,2, Yulia Albertovna Gallyamova1, Olga Andreevna Korableva2, A Randomized Study of Biomimetic Peptides Efficacy and Impact on the Growth Factors Expression in the Hair Follicles of Patients with Telogen Effluvium. Journal of Applied Pharmaceutical Science Vol. 8(04), pp 015-022, April, 2018. DOI: 10.7324/JAPS.2018.8403.