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  • Presentation

Global Burden of Atopic Dermatitis: Building a Living Atlas, Evidence Base, and Research Network

Description

The talk describes the GADA initiative to create a global, living atlas of atopic dermatitis burden, inspired by the Global Psoriasis Atlas and WHO psoriasis work. It aims to fill major data gaps by combining a continuously updated evidence base, field studies, and practical recommendations for governments, clinicians, and patient groups. The speaker outlines a comprehensive inaugural report covering prevalence, incidence, stigma, work impact, comorbidities, and treatment, and notes major regional gaps, especially in Africa, as well as wide methodological inconsistency across studies. To address this, GADA is pursuing three main pillars: a living systematic review and Bayesian burden estimates; standardization of epidemiologic study methods through international consensus; and a digital ecosystem for collecting standardized data. The team has completed a large scoping review and an even larger systematic review screening over 30,000 records, with about 1,100 studies included. Additional projects include new patient registers in Lebanon, Nigeria, and India; a photo atlas integrated with the website; an omics project studying skin barrier and immune signatures in diverse cohorts; a SkinDeep project on language and images in diverse populations; and a pregnancy and lactation study. GADA is also supporting early-career researchers through fellowships and building a broad international collaboration network.

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Conclusions

  • The presentation concludes that atopic dermatitis has major global burden but current epidemiologic data remain patchy, heterogeneous, and especially sparse in regions such as Africa.
  • It concludes that a living global atlas with annually updated evidence synthesis is needed to continually quantify prevalence, incidence, and comorbidities.
  • It concludes that methodological inconsistency in case ascertainment, severity measurement, and study design limits comparability across studies and must be standardized.
  • It concludes that an international consensus on core epidemiologic items is achievable and should guide future burden studies.
  • It concludes that digital registers and field studies are a practical way to generate standardized real-world data in countries where evidence gaps are largest.
  • It concludes that expanding research beyond high-income settings is essential to understand atopic dermatitis across diverse populations and phenotypes.
  • It concludes that multi-omics work may help explain clinical heterogeneity and link biological signatures to different disease presentations and environments.
  • It concludes that skin image and language studies can improve understanding of how ancestry and background shape patient descriptions, diagnosis, and engagement.
  • It concludes that pregnancy and lactation are under-studied periods in atopic dermatitis care and require dedicated mixed-methods research.
  • It concludes that building global capacity through fellowships and collaboration is important for sustaining future atopic dermatitis research.
  • Br J Dermatol 2023 doi: 10.1093/bjd/ljad286.#10.1093/bjd/ljad286
  • Atopic dermatitis epidemiological research methodology: a global scoping review.#10.1093/bjd/ljaf238