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  • Presentation

Frontal Fibrosing Alopecia: Update on Treatment 2025

Description

The presentation discusses advancements in the treatment of Frontal Fibrosing Alopecia (FFA), emphasizing personalized approaches based on patient demographics and health status. It highlights the significance of managing patient expectations, primarily focusing on stabilizing the condition rather than promising improvements. Various treatment options are divided by disease phases: early interventions may include 5-alpha reductase inhibitors to prevent inflammation, while established inflammation might require anti-inflammatory treatments like hydroxychloroquine or topical calcineurin inhibitors. Novel therapies such as dutasteride have shown promise, achieving stabilization in a significant percentage of patients. Other treatments mentioned include oral minoxidil for hair density, PRP for skin improvement, and various options for aesthetic enhancement, such as scalp micro pigmentation and wigs. The importance of continuous evaluation and adaptation of treatment protocols, as well as staying updated on new therapies, is emphasized. Current therapeutic recommendations involve a combination of topical treatments, oral medications, and cosmetic procedures to enhance patients' quality of life. The discussion concludes with optimism for future research and potential breakthroughs in treating FFA.

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Conclusions

  • The treatment for frontal fibrosing alopecia must be individualized based on patient age and condition severity.
  • The primary goal of treatment is to stabilize the condition and prevent disease progression.
  • Oral dutasteride is effective as a first-line treatment option, achieving stabilization in approximately 63% of patients.
  • Higher doses of dutasteride correlate with better stabilization outcomes in patients.
  • Adjunct treatments like oral minoxidil can improve hair density in patients with frontal fibrosing alopecia, particularly in the eyebrows.
  • Platelet-rich plasma (PRP) has shown potential anti-inflammatory effects for patients suffering from frontal fibrosing alopecia.
  • Cosmetic measures such as micropigmentation and wigs can significantly improve the quality of life for patients in advanced stages of the disease.
  • There is a need for patient education regarding realistic treatment expectations in managing frontal fibrosing alopecia.
  • Vañó-Galván S, Molina-Ruiz AM, Serrano-Falcón C, Arias-Santiago S, Rodrigues-Barata AR, Garnacho-Saucedo G, Martorell-Calatayud A, Fernández-Crehuet P, Grimalt R, Aranegui B, Grillo E, Diaz-Ley B, Salido R, Pérez-Gala S, Serrano S, Moreno JC, Jaén P, Camacho FM. Frontal fibrosing alopecia: a multicenter review of 355 patients. J Am Acad Dermatol. 2014 Apr;70(4):670-678. doi: 10.1016/j.jaad.2013.12.003. Epub 2014 Feb 5. PMID: 24508293
  • Kanti V, Constantinou A, Reygagne P, Vogt A, Kottner J, Blume-Peytavi U. Frontal fibrosing alopecia: demographic and clinical characteristics of 490 cases. J Eur Acad Dermatol Venereol. 2019 Oct;33(10):1976-1983. doi: 10.1111/jdv.15735. Epub 2019 Jul 1. PMID: 31179579
  • McSweeney SM, Christou EAA, Dand N, Boalch A, Holmes S, Harries M, Palamaras I, Cunningham F, Parkins G, Kaur M, Farrant P, McDonagh A, Messenger A, Jones J, Jolliffe V, Ali 1, Ardern-Jones M, Mitchell C, Burrows N, Atkar R, Banfield C, Alexandroff A, Champagne C, Cooper HL, Patel GK, Macbeth A, Page M, Bryden A, Mowbray M, Wahie S, Armstrong K, Cooke N, Goodfield M, Man I, de Berker D, Dunnil G, Takwale A, Rao A, Siah TW, Sinclair R, Wade MS, Bhargava K, Fenton DA, McGrath JA, Tziotzios C. Fron
  • Doche I, Romiti R, Rivitti-Machado MC, Gorbatenko-Roth K, Freese RL, Hordinsky MK. Quality-of-life impairment is not related to disease activity in lichen planopilaris and frontal fibrosing alopecia. Results of a preliminary cross-sectional study. J Eur Acad Dermatol Venereol. 2022 Apr;36(4):e288-e290. doi: 10.1111/jdv.17798. Epub 2021 Nov 18. PMID: 34753220
  • Seo HM, Oh SU, Kim S, Park JH, Kim JS. Dutasteride in the treatment of frontal fibrosing alopecia: Systematic review -NEW and meta-analysis. J Eur Acad Dermatol Venereol. 2024 Feb 15. doi: 10.1111/jdv.19802. Online ahead of print. PMID: 38357767
  • Pindado-Ortega C, Saceda-Corralo D, Moreno-Arrones ÓM, Rodrigues-Barata AR, Hermosa-Gelbard Á, Jaén-Olasolo P, Vañó-Galván S. Effectiveness of dutasteride in a large series of patients with frontal fibrosing alopecia in real clinical practice. J Am Acad Dermatol. 2021 May;84(5):1285-1294. doi: 10.1016/j.jaad.2020.09.093. Epub 2020 Oct 7. PMID: 38357767
  • García A, Navarro MR, Ramirez A, Pino A, Navarro A, Moles I, Gallego E, Anitua E. Plasma Rich in Growth Factors as an Adjuvant Treatment for the Management of Frontal Fibrosing Alopecia: A Retrospective Observational Clinical Study. J Cutan Med Surg. 2023 Jul-Aug;27(4):340-349. doi: 10.1177/12034754231177599. Epub 2023 May 26. PMID: 37233603