Forever Chemicals and Human Health: An Introduction to PFAS for the Dermatologist

Dr. Anika Belzer, a dermatology resident at UCSF, presents on the impact of PFAS (perfluoroalkyl and polyfluoroalkyl substances), commonly known as forever chemicals, on human health, especially in dermatology. PFAS are widespread synthetic compounds found in various industries, including personal care products, leading to constant human exposure through inhalation, ingestion, and skin absorption. The presentation outlines the history of PFAS, including early health concerns noted by manufacturers and studies indicating health impacts since the 1960s. Notably, PFAS exposure has been linked to disorders such as hyperlipidemia, thyroid disease, autoimmune conditions, and various cancers, including testicular and kidney cancers. The effects on dermatological conditions are discussed, highlighting potential associations between PFAS exposure and inflammatory skin diseases like atopic dermatitis and psoriasis. The alarming find of PFAS in nearly all tested personal care products raises concerns for dermatologists regarding skin health and product ingredients. Dr. Belzer stresses the need for further research to understand the implications of emerging PFAS compounds on skin diseases, given the shift away from regulated legacy PFAS, and calls for greater awareness among clinicians to effectively advise patients and promote public health.