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  • Presentation

Follicular Rescue in Scarring Alopecias: Treating to Halt Disease Progression and Grow Hair

Description

Rhonda, a dermatologist from the University of Minnesota, discusses follicular rescue strategies in scarring alopecias, focusing on treatments aimed at halting disease progression and promoting hair growth. She emphasizes that many procedures, including platelet-rich plasma (PRP) and exosome therapies, are administered off-label with limited FDA approval. Rhonda outlines how PRP is commonly used for androgenetic alopecia and suggests that its effectiveness in scarring alopecias, though based on case reports rather than robust studies, shows promise, particularly in younger female patients. She includes insights on exosomes, explaining their composition and regulatory status, and warns of potential safety issues, including the risk of contamination and blood doping. Additionally, she highlights the rising trend of scalp spas that combine therapeutic treatment with holistic wellness, advocating that dermatologists should integrate such approaches while maintaining patient safety and regulatory standards. Rhonda also touches upon energy-based devices and microneedling for hair regrowth, the critical evaluation of hair transplantation techniques in scarring alopecia, and the significance of biopsies prior to any surgical intervention. Lastly, she expresses her intention to create a scalp treatment room in her clinic, bridging professional and holistic care while navigating current hair loss trends in the skincare market.

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Conclusions

  • Exosomes are not FDA approved for injection and thus present a safety concern.
  • Platelet-rich plasma (PRP) therapy shows variable results in treating scarring alopecias.
  • There is a lack of high-quality evidence on the effectiveness of PRP and exosomes for hair regrowth in scarring alopecia.
  • While some reports indicate benefits from PRP in patients with lichen planopilaris and central centrifugal cicatricial alopecia, these are often limited to case reports.
  • Energy-based procedures, including photobiomodulation and laser therapies, show promise but require more rigorous research to establish efficacy.
  • Microneedling appears to be a potential adjunct to treatment for alopecia but lacks sufficient evidence to recommend it as a standalone treatment.
  • Cosmetic procedures such as scalp spas are gaining popularity and may integrate well with professional treatments for hair loss.
  • Patient education on the potential risks and variable efficacy of new treatments is crucial for informed decision-making in managing scarring alopecias.
  • Javed A. Shaik , Nima Estharabadi, Ronda S. Farah, Maria K. Hordinsky. Heterogeneity in amount of growth factors secreted by platelets in platelet-rich plasma samples from alopecia patients. Experimental Dermatology, ORIGINAL RESEARCH ARTICLE | Full Access. First published: 03 August 2020 | https://doi-org.ezp3.lib.umn.edu/10.1111/exd.14165 | Citations: 1
  • Amelia K Hausauer, Shannon Humphrey. The Physician's Guide to Platelet-Rich Plasma in Dermatologic Surgery Part I: Definitions, Mechanisms of Action, and Technical Specifications. Dermatol Surg. 2020 Mar;46(3):348-357. doi: 10.1097/DSS.0000000000002147.
  • Abhijeet Kumar Jha, Dina, Yemisi BS; Aguh, Crystal MD. Platelet-rich plasma as a novel treatment for lichen planopillaris. Dermatol Ther. 2016 Jul;29(4):233-5. doi: 10.1111/dth.12343. Epub 2016 Mar 14.