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- Presentation
F040 Vitiligo: Evidence Based Medicine Applied to Cases - Co-Morbidities
Description
Professor Victoria Theradu discusses the comorbidities associated with vitiligo, emphasizing both autoimmune disorders and psychosocial issues that patients face. She highlights findings from extensive genome-wide association studies which indicate a shared genetic background between vitiligo and other autoimmune diseases, noting that individuals with vitiligo are at an increased risk for various autoimmune conditions. Moreover, she draws attention to the significant psychosocial effects, such as heightened levels of anxiety and depression, particularly among certain demographics like adolescents and those with visible skin lesions. Theradu references UK studies showing that a majority of newly diagnosed vitiligo patients do not receive any treatment, while a smaller percentage are prescribed antidepressants and anxiolytics to help manage their condition. She stresses the need for routine screening for thyroid disorders and psychosocial stressors during clinical assessments. Theradu also presents clinical cases that illustrate the effectiveness of home phototherapy combined with appropriate management strategies, aiming to empower patients and enhance their treatment outcomes. In conclusion, she recommends regular thyroid assessments and psychological evaluations for patients with vitiligo, along with the incorporation of home phototherapy as a safe treatment option.
View moreConclusions
- Individuals with vitiligo have a genetic predisposition to various autoimmune diseases.
- Patients with vitiligo exhibit significant psychosocial comorbidities such as anxiety and depression.
- Older age, later onset, and longer disease duration correlate with an increased risk of autoimmune diseases in vitiligo patients.
- Early onset of vitiligo (before age 12) is associated with a lower prevalence of autoimmune thyroid disease.
- The presence of reactive oxygen species can exacerbate both vitiligo and associated autoimmune conditions like thyroid disease.
- The field of vitiligo management requires a more vigilant approach to assess and address psychological distress.
- All patients diagnosed with vitiligo should be screened for thyroid function and autoantibodies due to their increased risk for thyroid disorders.
- Home phototherapy is a safe and effective treatment and should be implemented with patient education.
- Clinical practice should adapt to provide timely interventions for both the physical and psychological aspects of vitiligo.
- Jin Y, Andersen et al. Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants. Nat Genet. 2016 Nov;48(11):1418-1424.
- Hu Z and Wang T (2023) Beyond skin white spots. Vitiligo and associated comorbidities. Front. Med. 10:1072837.
- Ezzedine K, Eleftheriadou V, Jones H, et al. Psychosocial Effects of Vitiligo: A Systematic Literature Review. Am J Clin Dermatol. 2021;22(6):757-774.
- Eleftheriadou V, et al British Association of Dermatologists guidelines for the management of people with vitiligo 2021. Br J Dermatol. 2022, 186:18-29.
- Eleftheriadou et al. Trials 2014, 15:51. Feasibility, double-blind, randomised, placebo-controlled, multi-centre trial of hand-held NB-UVB phototherapy for the treatment of vitiligo at home (HI-Light trial: Home Intervention of Light therapy).