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  • Presentation

Dysplastic Nevi for Dummies

Description

The presentation on dysplastic nevi begins with introductions from Elizabeth Berry, an associate professor at Oregon Health and Science University, alongside Dr. Ben Stoff from Emory University and Michael Teslaf from UCSF. The session aims to clarify the complexities surrounding the diagnosis of dysplastic nevi, outline a management algorithm based on the latest literature, and discuss molecular techniques for evaluating the malignant potential of these lesions. Berry emphasizes the importance of understanding histologically dysplastic nevi in relation to clinically atypical nevi and the challenges involved in accurate diagnosis, including the nuances of biopsy margin status. Effective management strategies and the significance of thorough skin examinations are highlighted, drawing analogies with searching for clovers to illustrate the intricacies of identifying and evaluating dysplastic nevi. The talk also outlines the classification of nevi and provides an overview of epidemiological data, noting varying prevalence rates among different demographics. The presentation aims to equip attendees with foundational knowledge and current insights into dysplastic nevi, setting the stage for Dr. Stoff's in-depth exploration of their histological characteristics.

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Conclusions

  • Dysplastic nevi (DN) have unique histological features that distinguish them from common nevi.
  • There is considerable controversy surrounding the diagnosis of dysplastic nevi.
  • Margin status in biopsies of dysplastic nevi is often unreliable, with many pathologists not reporting it.
  • Recent studies suggest that a significant percentage of DN with negative margins may still have positive margins upon re-excision.
  • Dysplastic nevi can be categorized as mild, moderate, or severe based on architectural disorder and cytologic atypia.
  • There is a correlation between clinical and histologic atypia, but it is often poor.
  • Management strategies for dysplastic nevi should incorporate recent data and advancements in molecular techniques to assess malignant potential.
  • Picket 2011
  • James 2011
  • Bolongia 2012
  • Tokachjov 2017
  • Sellheyer 2005
  • Chang 2009
  • Zakhem 2018
  • Adaji 2016
  • Piepkorn 1989