Cutaneous Lymphoma and Disorders of Systemic Disease: Updates and Potential Gaps

Conclusions

• Mycosis fungoides can have multiple non-classic subtypes, including hyperpigmented and folliculotropic variants that may complicate diagnosis.
• There is a notable overlap between different forms of cutaneous T cell lymphomas and benign conditions, which can lead to misdiagnosis.
• Gamma delta T cell receptor expression can occur in lymphomatoid papulosis and other similar conditions, challenging the perception of aggressive behavior associated with this immunophenotype.
• Histological and immunophenotypic characteristics of lymphomatoid papulosis show variability, which suggests that existing definitions might not be universally applicable.
• Dupilumab may increase the risk of developing cutaneous T cell lymphoma in patients with atopic dermatitis, necessitating careful monitoring.
• The use of next-generation sequencing for assessing T cell receptor clonality is more sensitive and specific than traditional methods, highlighting gaps in existing diagnostic practices.
• Dupilumab therapy can unmask underlying lymphoma in patients who may already have an indolent disease prior to treatment.