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  • Presentation

Common, Uncommon, and Rare Presentations of Vitiligo

Description

The presentation on vitiligo focuses on its various forms, specifically distinguishing between common segmental and non-segmental vitiligo, and discusses the signs indicative of disease activity. The speaker reviews the epidemiology of vitiligo, noting its prevalence of about 0.6% diagnosed by physicians, potentially rising to 1% when considering undiagnosed cases. The presentation also highlights the significant stigma surrounding the disorder, emphasized by a study revealing high exclusion rates in job descriptions for individuals with vitiligo. The speaker explains how vitiligo can present unusually, including rare forms and signs of activity, such as confetti-like pigmentation, trichrome lesions, and the Koebner phenomenon, which may indicate ongoing disease progression. Distinctions between segmental and non-segmental vitiligo in terms of onset and autoimmune associations are critical for effective treatment. The importance of thorough patient history, screening for autoimmune issues, and visual examinations via Wood’s lamp is stressed. The development of a score for assessing activity in vitiligo is discussed as a tool for monitoring disease progress and treatment efficacy. The conclusion emphasizes the necessity for clinicians to identify the type of vitiligo, perform comprehensive assessments, and consider hair color when discussing repigmentation potential with patients, ensuring they receive accurate prognostic information.

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Conclusions

  • The prevalence of vitiligo is approximately 0.6-1%, with most cases starting before the age of 20.
  • Vitiligo can be classified into segmental and non-segmental forms, with different clinical presentations and prognoses.
  • Non-segmental vitiligo is often progressive with multiple flare-ups, while segmental vitiligo tends to stabilize quickly after rapid onset.
  • Signs of vitiligo activity include confetti-like pigmentation, Koebner phenomenon, and trichrome lesions, with confetti-like lesions indicating a negative prognosis.
  • There is a significant stigma associated with vitiligo, impacting employment opportunities and psychological well-being.
  • Thyroid autoimmunity screening is advised for patients with non-segmental vitiligo, especially in adults.
  • Daily activities can exacerbate vitiligo, highlighting the importance of identifying triggers during patient consultations.
  • The Vitiligo Signs of Activity Score (VSAS) aids in the assessment of disease activity and prognosis for patients, allowing for tailored treatment approaches.
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  • K. Ezzedine, et al. Hypochromic vitiligo: delineation of a new entity. BJD. 2022 May;36(5):e361-e362. doi: 10.1111/jdv.17884.
  • Benzekri et al. Vitiligo Potential Repigmentation Index: a simple clinical score that might predict the ability of vitiligo lesions to repigment under therapy. Br J Dermatol. 2013 May;168(5):1143-6.
  • Van Geel, N, et al. Reliability and validity of the Vitiligo Signs of Activity Score (VSAS). Br J Dermatol 2020; 183(5):883-90.