Clinicopathologic Self-Assessment

The presentation involves a clinical-pathologic self-assessment focused on dermatologic cases from a free clinic. The speaker, who has no conflicts of interest to disclose, presents various skin lesions and their histological findings while encouraging audience participation through diagnoses and discussions. The first case features an ulcerated lesion, diagnosed as an epithelioid cell histiocytoma, with significant discussion on its histological characteristics, immunostains, and fast growth patterns, including details about ALK rearrangements often seen in such tumors. This segment emphasizes the importance of distinguishing this condition from other dermatological issues, such as melanoma and dermatofibromas. The second case involves a 42-year-old woman with an erosive nipple lesion, diagnosed through biopsy. It highlights the uncertainty involved in cases of papillary lesions of the breast, emphasizing the need for complete excision for definitive diagnosis and follow-up screenings due to potential associations with breast cancer. The speaker elucidates various differential diagnoses, including nipple adenoma and syringocystadenoma papiliferum, and advises on the management of these lesions. The cases demonstrate the complexities of dermatopathology and the importance of thorough clinical assessment and precise diagnostic techniques in establishing appropriate treatment plans.